Etomidate (commercial name Amidate) is a short-acting anesthetic agent which is administered intravenously to achieve anesthesia and sedation for medical purposes, e.g. for knuckle reduction or tracheal intubation, cardiac and electroconvulsive therapy. It is used as an anaesthetic because it has a rapid onset of action and is safe for cardiovascular disorders without causing a sharp fall in blood pressure and limited suppression of ventilation, it does not release histamine and protects against ischaemia of the myocardium and the brain. It is used in craniocerebral trauma because this anaesthetic is able to lower intracranial pressure and maintain normal arterial pressure, and it is also used before lobectomy in brain surgery. Etomidate has been used for lethal executions in the United States.
This drug was first developed at Janssen Pharmaceutica in 1964 and was used in medicine after 1972.
Simultaneous use of etomidate with benzodiazepines, opioids and other sedatives can lead to adrenal insufficiency.
Etomidate reduces cortisol levels for 72 hours after injection. Etomidate at low doses affects GABA receptors, β2 and β3 subunits.
With the usual dosage of etomidate, anesthesia occurs within 5-10 minutes.
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Etomidate is a new designer drug designed for research and forensics.
Toxicological and physiological properties of Etomidate have not been studied.
Etomidate synthesized in the modern laboratory in compliance with all standards.
|Purity||≥ 98 %|
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